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#Eaqually contributed * corresnponding author
2024
１. Yanagiya R, Miyatake Y, Watanabe N, Shimizu T, Kanamori A, Ueno M, Okabe S, Carreras J, Nakayama S, Hasegawa A, Kameda K, Kamakura T, Nakagawa S, Yamauchi T, Maeda T, Ishii K, Matsuura T, Handa H, Hirao A, Ishizawa K, Onizuka M, Mashima T, Nakamura N, Ando K, Kotani A.
Amino acid influx via LAT1 regulates iron demand and sensitivity to PPMX-T003 of aggressive natural killer cell leukemia.
Leukemia. 2024 Jun 24. doi: 10.1038/s41375-024-02296-6. Online ahead of print.
PMID: 38914715
2. Miura H, Nakamura A, Kurosaki A, Kotani A, Motojima M, Tanaka K, Kakuta S, Ogiwara S, Ohmi Y, Komaba H, Schilit SLP, Morton CC, Gurumurthy CB, Ohtsuka M.
Targeted insertion of conditional expression cassettes into the mouse genome using the modified i-PITT.BMC Genomics. 2024 Jun 5;25(1):568. doi: 10.1186/s12864-
３. # Kudo K, #Yanagiya R, *Hasegawa M, Carreras J, Miki Y, Nakayama S, Nagashima E, Miyatake Y, Torii K, Ando K, Nakamura N, Miyajima A, Murakami M, *Kotani A.Unique lipid composition maintained by extracellular blockade leads to prooncogenicity. Cell Death and Discovery 2024, 221
2023
1. #Kameda K, #Yanagiya R, #Miyatake Y, Carreras J, Higuchi H, Murayama H, Ishida T, Ito A, Iida S,Fukuhara N, Harigae H, Fujioka Y, Takahashi N, Wada H, Ishida F, Nakazawa H, Ishihara R,Murakami Y, Tagawa H, Matsuura T, Nakagawa S, Iwabuchi S , Hashimoto S, Imadome KI, Nakamura N, Ishizawa K, Kanda Y, Ando K, *Kotani A.
Hepatic niche leads to aggressive NK-cell leukemia proliferation through transferrin-transferrin receptor 1 axis
BLOOD (IF25) 2023 Jul 27;142(4):352-364.
2. Otsuka M and *Kotani A. Recent advances in extracellular vesicles in gastrointestinal cancer and lymphoma.
Cancer Science 2023 Jun;114(6):2230-2237
3.
Ishihara S, Sato M, Miyazaki H, Saito H, Sato T, Fujikado N, Sawai S, Kotani A, *Katagiri K. Deletion of miR-150 Prevents Spontaneous T Cell Proliferation and the Development of Colitis. Gastro Hep Advances 2023. 2, 487-496.
2022
１．Kudo K, Miki Y, Carreras J, Nakayama S, Nakamoto Y, Ito M, Nagashima E, Yamamoto K, Higuchi H, Morita SY, Inoue A, Aoki J, Ando K, Nakamura N,
＊Murakami M, ＊Kotani A. Secreted phospholipase A2 modifies extracellular vesicles and accelerates B cell lymphoma.
Cell Metab. （IF30) 2022, 34, 615-633.e8.
2．#Yamamoto Y, #Carreras J, #Shimizu T, Kakizaki M, Ykikuti YY, Roncador G, Nakamura N and , ＊Kotani A. Anti-HBV drug entecavir ameliorates DSS-induced colitis through PD-L1 induction
Pharmacol. Res.（IF10) 2022, 179, 105918.
３．Ceramide Metabolism Regulated by Sphingomyelin Synthase 2 Is Associated with Acquisition of Chemoresistance via Exosomes in Human Leukemia Cells.
Makoto Taniguchi, Shingo Nagaya, Kohei Yuyama, Ai Kotani, Yasuyuki Igarashi, Toshiro Okazaki
International journal of molecular sciences 23(18) 2022年9月13日
4. The RNA-Binding Protein ELAVL1 Regulates Hepatitis B Virus Replication and Growth of Hepatocellular Carcinoma Cells.
Hiroaki Kanzaki, Tetsuhiro Chiba, Tatsuya Kaneko, Junjie Ao, Motoyasu Kan, Ryosuke Muroyama, Shingo Nakamoto, Tatsuo Kanda, Hitoshi Maruyama, Jun Kato, Yoh Zen, Ai Kotani, Kazuma Sekiba, Motoyuki Otsuka, Masayuki Ohtsuka, Naoya Kato
International journal of molecular sciences 23(14) 2022年7月17日
2021
1. Kakizaki M#, Yamamoto Y#, Nakayama S#, KamedaK, Nagashima E, Ito M, Suyama T, Matsuzaki Y, Chiba T, Sumiyoshi H, Inagaki Y, and *Kotani A
Human hepatocyte-derived extracellular vesicles attenuate the carbon tetrachloride-induced acute liver injury in mice
Cell death and disease (IF 8.6) in press
2. *Kotani A, Ito M, Kudo K
Non-coding RNAs and lipids mediate the function of extracellular vesicles in cancer cross-talk
Seminars in Cancer Biology (IF 15.7) in press 【review】
3. Kawashima M, *Kotani A
Exosome, lymphoid malignancy, trogocytosis, tumor microenvironment
Journal of clinical and experimental hematopathology in press 【review】
4. Ishihara S, Sato T, Sugioka R, Miwa R, Saito H, Sato R, Fukuyama H, Nakajima A, Sawai S, Kotani A, Katagiri K. Rap1 Is Essential for B-Cell Locomotion, Germinal Center Formation and Normal B-1a Cell Population.
Front Immunol. 2021 Jun 1;12:624419. doi: 10.3389/fimmu.2021.624419. eCollection 2021.
5. Ito M# Kudo K# ,Higuchi H, Otsuka H,Tanaka M, Fukunishi N,Araki K, Takamatsu M, Ino Y ,Kimura Y, *Kotani A.
Proteomic and phospholipidomic characterization of extracellular vesicles inducing tumor microenvironment in Epstein-Barr virus-associated lymphomas.
FASEB J. 2021, 35(4):e21505.
6. *Nakagawa S#, Kawashima M#, Miyatake Y#, Kudo K, Kotaki R, Ando K, *Kotani A.
Expression of ERV3-1 in leukocytes of acute myelogenous leukemia patients.
Gene. 2021,773 145363 - 145363
2020
1. Kakizaki M, Yamamoto Y, Otsuka M, Kitamura K, Ito M, Kawai H-D,Muramatsu M, Kagawa K,*Kotani A.
Extracellular vesicles secreted by HBV-infected cells modulate HBV persistence in hydrodynamic HBV transfection mouse model.
J. Biol. Chem.2020,295(35):12449-12460,
2. Yamamoto Y, Kakizaki M, Shimizu T, Carreras J, Chiba T, Chamoto K, Kagawa T, Aoki T, Nakamura N, Ando K, *Kotani A
PD-L1 is induced on hepatocyte surface via CKLF-like MARVEL transmembrane domain-containing protein 6 up-regulation by the anti-HBV drug Entecavir Int. Immunol. 2020,32(8):519-531
3. Kotaki R, Kawashima M, Yamamoto Y, Higuchi H, Nagashima E, Kurosaki N, Takamatsu M, Kikuti YY, Imadome KI, Nakamura N, *Kotani A.
Dasatinib exacerbates splenomegaly of mice inoculated with Epstein-Barr viru-sinfected lymphoblastoid cell lines. Sci Rep.2020, 10(1):4355
4. Kotaki R, Kawashima M, Yamaguchi A, Suzuki N, Koyama-Nasu R, Ogiya D, Okuyama K, Yamamoto Y, Takamatsu M, Kurosaki N, Ando K, Murata A, Ohtsuka M, Nakagawa S, Katagiri K, *Kotani A
Overexpression of miR-669m inhibits erythroblast differentiation.
Sci. Rep. 2020,10:13554
5. Koike R, Nodomi K, Watanabe N, Ogata Y, Takeichi O, Takei M, Kaneko T, Tonogi M, Kotani AI, Imai K
Butyric Acid in Saliva of Chronic Periodontitis Patients Induces Transcription of the EBV Lytic Switch Activator BZLF1: A Pilot Study In Vivo. 2020 Mar-Apr;34(2):587-594.
6. Kawashima M, Carreras J, Higuchi H, Kotaki R, Hoshina T, Okuyama K, Suzuki N, Kakizaki M, Miyatake Y, Ando K, Nakayama M, Umezu S, Horie R, Higuchi Y, Katagiri K, Goyama S, Kitamura T, Chamoto K, Yano S, Nakamura N, Kotani A
PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma.
Leukemia. 2020 Feb 24. doi: 10.1038/s41375-020-0737-9.
7. Kotaki R#, Kawashima M#, Yamamoto Y#, Higuchi H, Nagashima E, Kurosaki N, Takamatsu M, Kikuti YY, Imadome KI, Nakamura N, Kotani A.* equally contributed first author
Dasatinib exacerbates splenomegaly of mice inoculated with Epstein-Barr virus-infected lymphoblastoid cell lines. Kotaki R, et al. Among authors: Kotani A. Sci Rep. 2020 Mar 9;10(1):4355. doi: 10.1038/s41598-020-61300-y.Sci Rep. 2020. PMID: 32152351 Free PMC article.
2019
1. Yasuhiro Katahira,# Hiroshi Higuchi,# Hiromichi Matsushita,Takashi Yahata, Yuichiro Yamamoto, Ryo Koike, Kiyoshi Ando,Katsuaki Sato, Ken-Ichi Imadome, and Ai Kotani
Increased Granulopoiesis in the Bone Marrow following Epstein-Barr Virus Infection
Sci Rep. 2019; 9: 13445.
Web
2.Watanabe N, Nodomi K, Koike R, Kato A, Takeichi O, Kotani A, KanekoT,Sakagami H, Takei M, Ogata Y, Sato S, Imai K
EBV LMP1 in Gingival Epithelium Potentially Contributes to Human Chronic Periodontitis via Inducible IL8 Production
In Vivo , 33 (6), 1793-1800
Web
2018
1.Masatoshi Kakizaki, Yuichiro Yamamoto, Suemi Yabuta, Natsumi Kurosaki, Tatehiro Kagawa, Ai Kotani
The immunological function of extracellular vesicles in hepatitis B virus-infected hepatocytes
PLoS ONE 13(12): e0205886
Web
2 .Higuchi H, Yamakawa N, Imadome KI, Yahata T, Kotaki R, Ogata J, Kakizaki M, Fujita K, Lu J, Yokoyama K, Okuyama K, Sato A, Takamatsu M, Kurosaki N, Alba SM, Azhim A, Horie R, Watanabe T, Kitamura T, Ando K, Kashiwagi T, Matsui T, Okamoto A, Handa H, Kuroda M, Nakamura N, Kotani A.
Role of exosomes as a proinflammatory mediator in the development of EBV-associated lymphoma.
Blood. 2018 Jun 7;131(23):2552-2567.Web
2017
1. Kotaki R, Higuchi H, Ogiya D, Katahira Y, Kurosaki N, Yukihira N, Ogata J, Yamamoto H,
Mohamad Alba S, Azhim A, Kitajima T, Inoue S, Morishita K, Ono K, Koyama-Nasu R, Kotani A.
Imbalanced expression of polycistronic miRNA in acute myeloid leukemia.
International Journal of Hematology. 2017;pp1-9. (Springer Japan)  Web
2. Kotaki R, Kotani A.
A single miRNA complements transcription factor deficiency through the TGF pathway at time of
B-cell lineage determination.
Rinsho Ketsueki. 2017;58(7):792-797.  Web
3. Kotanki R, Nasu-Koyama R, Yamakawa N, and Kotani A.
miRNAs in Normal and Malignant Hematopoiesis.
International Journal of Molecular Sciences. 2017;18(7). pii: E1495.  Web
2016
1. Kotani A.
Roles of Epstein–Barr Virus Micro RNAs in Epstein–Barr Virus-Associated Malignancies.
Chronic Inflammation Mechanisms and Regulation. 2016;235-45. (Springer Japan)  Web
2. Kishikawa T, Otsuka M, Yoshikawa T, Ohno M, Yamamoto K, Yamamoto N, Kotani A, Koike K.
Quantitation of circulating satellite RNAs in pancreatic cancer patients.
JCI insight. 2016;1(8). e86646.  Web
3. Yamamoto H, Lu J, Oba S, Kawamata T, Yoshimi A, Kurosaki N, Yokoyama K, Matsushita H,
Kurokawa M, Tojo A, Ando K, Morishita K, Katagiri K, Kotani A.
miR-133 regulates Evi1 expression in AML cells as a potential therapeutic target.
Scientific Reports. 2016;6:19204.  Web
4. Sato A, Yamakawa N, Kotani A.
Pathogenesis and novel therapy for EBV-related B-cell lymphoma.
Rinsho Ketsueki. 2016;57(1):3-8.  Web
5. 扇屋大輔, 山本春菜, 幸谷愛
miRNAによる予後不良白血病の制御
別冊BIO Clinica Vol.5 No.1 (2016年1月号) CLINICAL TOPICS (北隆館)  Web
2014
1. Sato A, Yamakawa N, Kotani A.
The role of tumor-derived secretary small RNAs in EBV related lymphoma.
Uirusu. 2014;64(1):43-8.  Web
2. Yamakawa N, Okuyama K, Ogata J, Kanai A, Helwak A, Takamatsu M, Imadome K,
Takakura K, Chanda B, Kurosaki N, Yamamoto H, Ando K, Matsui H, Inaba T, Kotani A.
Novel functional small RNAs are selectively loaded onto mammalian Ago1.
Nucleic Acids Res. 2014;42(8):5289-301.  Web
3. Kotani A.
Guest editorial: noncoding RNA in hematopoietic system.
Int J Hematol. 2014;99(5):529-30.  Web
4. Okuyama K, Ogata J, Yamakawa N, Chanda B, Kotani A.
Small RNA as a regulator of hematopoietic development immune response in infection and
tumorigenesis.
Int J Hematol. 2014;99(5):553-60.  Web
5. Kotani A.
Genomic mutator Activation-induced cytidine deaminase (AID) as a therapeutic target.
Rinsho Ketsueki. 2014;55(7):780-4.  Web
6. 緒方洵, 保科貴宏, 山本春菜, 幸谷愛
RNA-RAN相互作用の新概念
実験医学 Vol.32 No.14 (2014年9月号) p.2271-5 (羊土社)  Web
7. 奥山一生, 幸谷愛
マイクロRNAによる血液細胞分化制御
血液内科 Vol.68 No.6 (2014年6月号) p.725-9 (科学評論社)  Web
2013
1. Okuyama K, Ikawa T, Gentner B, Hozumi K, Harnprasopwat R, Lu J, Yamashita R, Ha D,
Toyoshima T, Chanda B, Kawamata T, Yokoyama K, Wang S, Ando K, Lodish HF, Tojo A,
Kawamoto H, Kotani A.
MicroRNA-126-mediated control of cell fate in B-cell myeloid progenitors as a potential
alternative to transcriptional factors.
Proc Natl Acad Sci U S A. 2013;110(33):13410-5.  Web
2. Yokoyama K, Yokoyama N, Izawa K, Kotani A, Hozumi K, Tojo A.
In vivo leukemogenic potential of an interleukin-7 receptor α chain mutant in hematopoietic
stem and progenitor cells.
Blood. 2013 Dec 19;122(26):4259-63.  Web
3. 横山和明, 幸谷愛
血液疾患・免疫疾患におけるエクソソーム
細胞工学 Vol.32 No.1 (2013年1月号) p.32-7 (学研秀潤社)  Web
2012
1. Honjo T, Kobayashi M, Begum N, Kotani A, Sabouri S, Nagaoka H.
The AID Dilemma: Infection, or Cancer?
Adv Cancer Res. 2012;113:1-44.  Web
2. Kawamata T, Lu J, Sato T, Tanaka M, Nagaoka H, Agata Y, Toyoshima T, Yokoyama K,
Oyaizu N, Nakamura N, Ando K, Tojo A, Kotani A.
Imatinib mesylate directly impairs class switch recombination through down-regulation
of AID: its potential efficacy as an AID suppressor.
Blood. 2012;119(13):3123-7.  Web
3. Lu J, Chanda B, Kotani A.
Epstein-Barr Virus-Encoded miRNAs in Epstein-Barr Virus-Related Malignancy.
Hematology - Science and Practice. 2012;409-25.  Web
2011
1. 幸谷愛
microRNAの異常
みんなに役立つ悪性リンパ腫の基礎と臨床 改訂版 (2011年2月発行) p.60-5 (医薬ジャーナル社)  Web 
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